Passing as Privileged

Ordering as privileged information

We propose to accelerate the rate of convergence of the pattern recognition task by directly minimizing the variance diameters of certain hypothesis spaces, which are critical quantities in fast-convergence results. We show that the variance diameters can be controlled by dividing hypothesis spaces into metric balls based on a new order metric. This order metric can be minimized as an ordinal r...

Privileged communications.

Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds.

The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids were generated via nucleosidation of acetoxy-spiroacetal with a series of silylated nucleobases under Vorbrüggen conditions.

Sulfonyl fluorides as privileged warheads in chemical biology

Sulfonyl fluoride electrophiles have found significant utility as reactive probes in chemical biology and molecular pharmacology. As warheads they possess the right balance of biocompatibility (including aqueous stability) and protein reactivity. Their functionality is privileged in this regard as they are known to modify not only reactive serines (resulting in their common use as protease inhi...

Quinoline scaffold as a privileged substructure in antimicrobial drugs

Drug design is a complex issue that still lack general approach with proven reliability. Combinatorial chemistry and HTS techniques did not appear to be effort-effective. As an alternative we have the fragment based design and more recently so called the privileged structures approach. We believe that some structural subunits are especially effective in design of bioeffectors. However it is not...